The Manchester Hyatt is in downtown SD, which is a way popular place. It used to be a dive that everyone avoided like the plague until they rebuilt downtown with Horton Plaza, shops/restaurants, condos, and recently Petco Park, which you can walk to see a Padres game. Downtown is also very safe, so need need to worry. Mission Bay, a few miles north is where all the water activity is.....renting sailboats, jetskis, etc. The marinas are mostly over at Shelter Island or in Mission Bay, near the Hyatt Islandia. Little Italy and Old Town are good places to eat for sure. Seaport Village, which is a shopping area is nearby your hotel, too. The trolley does not go to the Wild Animal Park, which is up next to Escondido, about 30-35 miles or so from your hotel. You'll be inundated with things to do there, just enjoy and have a great time! You can walk to the Midway from your hotel. What is also neat to watch are the airplanes on approach that seam to snake thru the high rises (they actually don't) on approach to Lindbergh Field. Sit on the left side of the airplane when coming and you will see why.
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